This lists songs that hit number one on the charts in the US during 1942. If a song spent nonconsecutive weeks at number one, the number of weeks for each occurrence at the top is shown in parenthesis.
| Date | Artist - Title | Weeks at #1 |
| December 21 1941 – January 31 1942 | Glenn Miller - Chattanooga Choo Choo | 9 (6) |
| February 1 – 7 1942 | Glenn Miller - A String Of Pearls | 2 (1) |
| February 8 – 14 1942 | Woody Herman - Blues in the Night | 1 |
| February 15 – 21 1942 | Glenn Miller - A String Of Pearls | 2 (1) |
| February 22 – May 2 1942 | Glenn Miller - Moonlight Cocktail | 10 |
| May 3 – June 13 1942 | Jimmy Dorsey - Tangerine | 6 |
| June 14 – July 11 1942 | Harry James - Sleepy Lagoon | 4 |
| July 12 – September 5 1942 | Kay Kyser - Jingle, Jangle, Jingle | 8 |
| September 6 – October 24 1942 | Glenn Miller - (I've Got A Gal In) Kalamazoo | 7 |
| October 25 1942 – January 9 1943 | Bing Crosby - White Christmas | 11 |
9 different songs hit number one in the US during 1942.