This lists songs that hit number one on the charts in the US during 1943. If a song spent nonconsecutive weeks at number one, the number of weeks for each occurrence at the top is shown in parenthesis.
| Date | Artist - Title | Weeks at #1 |
| October 25 1942 – January 9 1943 | Bing Crosby - White Christmas | 11 |
| January 10 – February 6 1943 | Tommy Dorsey - There Are Such Things | 5 (4) |
| February 7 – 20 1943 | Harry James - I Had The Craziest Dream | 2 |
| February 21 – 27 1943 | Tommy Dorsey - There Are Such Things | 5 (1) |
| February 28 – May 22 1943 | Harry James - I've Heard That Song Before | 13 (12) |
| May 23 – 29 1943 | Glenn Miller - That Old Black Magic | 1 |
| May 30 – June 5 1943 | Harry James - I've Heard That Song Before | 13 (1) |
| June 6 – 26 1943 | Benny Goodman - Taking A Chance On Love | 3 |
| June 27 – July 17 1943 | Song Spinners - Comin' In On A Wing And A Prayer | 3 |
| July 18 – August 14 1943 | Dick Haymes - You'll Never Know | 4 |
| August 15 – September 4 1943 | Tommy Dorsey - In The Blue Of The Evening | 3 |
| September 5 – October 23 1943 | Bing Crosby - Sunday, Monday, Or Always | 7 |
| October 24 – 30 1943 | Al Dexter - Pistol Packin' Mama | 1 |
| October 31 1943 – January 22 1944 | Mills Brothers - Paper Doll | 12 |
12 different songs hit number one in the US during 1943.