This lists songs that hit number one on the charts in the US during 1945. If a song spent nonconsecutive weeks at number one, the number of weeks for each occurrence at the top is shown in parenthesis.
| Date | Artist - Title | Weeks at #1 |
| December 17 1944 – February 10 1945 | Bing Crosby and Andrews Sisters - Don't Fence Me In | 8 |
| February 11 – March 31 1945 | Andrews Sisters - Rum and Coca-Cola | 7 |
| April 1 – May 19 1945 | Les Brown - My Dreams Are Getting Better All The Time | 7 |
| May 20 – July 21 1945 | Les Brown - Sentimental Journey | 9 |
| July 22 – September 8 1945 | Johnny Mercer - On The Atchison, Topeka And The Santa Fe | 7 |
| September 9 – November 10 1945 | Perry Como - Till The End Of Time | 9 |
| November 11 – 17 1945 | Sammy Kaye - Chickery Chick | 3 (1) |
| November 18 – December 1 1945 | Harry James - It's Been A Long, Long Time | 3 (2) |
| December 2 – 8 1945 | Bing Crosby - It's Been A Long, Long Time | 1 |
| December 9 – 15 1945 | Sammy Kaye - Chickery Chick | 3 (1) |
| December 16 – 22 1945 | Harry James - It's Been A Long, Long Time | 3 (1) |
| December 23 – 29 1945 | Sammy Kaye - Chickery Chick | 3 (1) |
| December 30 1945 – January 12 1946 | Freddy Martin - Symphony | 2 |
10 different songs hit number one in the US during 1945.