This lists songs that hit number one on the charts in the US during 1949. If a song spent nonconsecutive weeks at number one, the number of weeks for each occurrence at the top is shown in parenthesis.
| Date | Artist - Title | Weeks at #1 |
| October 31 1948 – January 1 1949 | Dinah Shore - Buttons And Bows | 10 (9) |
| January 2 – 8 1949 | Spike Jones - All I Want For Christmas (Is My Two Front Teeth) | 1 |
| January 9 – 15 1949 | Dinah Shore - Buttons And Bows | 10 (1) |
| January 16 – March 5 1949 | Evelyn Knight - A Little Bird Told Me | 7 |
| March 6 – 19 1949 | Blue Barron - Cruising Down The River | 2 |
| March 20 – May 7 1949 | Russ Morgan - Cruising Down The River | 7 |
| May 8 – July 23 1949 | Vaughn Monroe - Ghost Riders In The Sky (A Cowboy Legend) | 11 |
| July 24 – August 27 1949 | Perry Como - Some Enchanted Evening | 5 |
| August 28 – September 24 1949 | Vic Damone - You're Breaking My Heart | 4 |
| September 25 – November 19 1949 | Frankie Laine - That Lucky Old Sun | 8 |
| November 20 – December 31 1949 | Frankie Laine - Mule Train | 6 |
10 different songs hit number one in the US during 1949.
Top 5 Songs of 1949

1: Vaughn Monroe Orchestra - Riders In The Sky
2: Frankie Laine - That Lucky Old Sun
3: Vic Damone - You're Breaking My Heart
4: Perry Como - Some Enchanted Evening
5: Jimmy Wakely and Margaret Whiting - Slipping Around
2: Frankie Laine - That Lucky Old Sun
3: Vic Damone - You're Breaking My Heart
4: Perry Como - Some Enchanted Evening
5: Jimmy Wakely and Margaret Whiting - Slipping Around