This lists songs that hit number one on the charts in the US during 1959. If a song spent nonconsecutive weeks at number one, the number of weeks for each occurrence at the top is shown in parenthesis.
| Date | Artist - Title | Weeks at #1 |
| December 21 1958 – January 17 1959 | Chipmunks - The Chipmunk Song | 4 |
| January 18 – February 7 1959 | Platters - Smoke Gets in Your Eyes | 3 |
| February 8 – March 7 1959 | Lloyd Price - Stagger Lee | 4 |
| March 8 – April 11 1959 | Frankie Avalon - Venus | 5 |
| April 12 – May 9 1959 | Fleetwoods - Come Softly To Me | 4 |
| May 10 – 16 1959 | Dave 'Baby' Cortez - The Happy Organ | 1 |
| May 17 – 30 1959 | Wilbert Harrison - Kansas City | 2 |
| May 31 – July 11 1959 | Johnny Horton - The Battle of New Orleans | 6 |
| July 12 – August 8 1959 | Paul Anka - Lonely Boy | 4 |
| August 9 – 22 1959 | Elvis Presley - A Big Hunk O' Love | 2 |
| August 23 – September 19 1959 | Browns - The Three Bells | 4 |
| September 20 – October 3 1959 | Santo and Johnny - Sleep Walk | 2 |
| October 4 – November 14 1959 | Bobby Darin - Mack The Knife | 9 (6) |
| November 15 – 21 1959 | Fleetwoods - Mr. Blue | 1 |
| November 22 – December 12 1959 | Bobby Darin - Mack The Knife | 9 (3) |
| December 13 – 26 1959 | Guy Mitchell - Heartaches By The Number | 2 |
| December 27 1959 – January 2 1960 | Frankie Avalon - Why | 1 |
16 different songs hit number one in the US during 1959.
Top 5 Songs of 1959
1: Johnny Horton - The Battle Of New Orleans
2: Bobby Darin - Mack The Knife
3: Lloyd Price - Personality
4: Frankie Avalon - Venus
5: Paul Anka - Lonely Boy
2: Bobby Darin - Mack The Knife
3: Lloyd Price - Personality
4: Frankie Avalon - Venus
5: Paul Anka - Lonely Boy