This lists songs that hit number one on the charts in the UK during 1959. If a song spent nonconsecutive weeks at number one, the number of weeks for each occurrence at the top is shown in parenthesis.
In the early years of the UK chart, occasionally two songs were at number one simultaneously. This will be indicated with two asterisks.
| Date | Artist - Title | Weeks at #1 |
| December 14 1958 – January 17 1959 | Conway Twitty - It's Only Make Believe | 5 |
| January 18 – 24 1959 | Jane Morgan - The Days The Rains Came | 1 |
| January 25 – February 14 1959 | Elvis Presley - I Got Stung / One Night | 3 |
| February 15 – March 14 1959 | Shirley Bassey - As I Love You | 4 |
| March 15 – 21 1959 | The Platters - Smoke Gets In Your Eyes | 1 |
| March 22 – April 18 1959 | Russ Conway - Side Saddle | 4 |
| April 19 – May 9 1959 | Buddy Holly - It Doesn't Matter Anymore | 3 |
| May 10 – June 13 1959 | Elvis Presley - A Fool Such As I / I Need Your Love Tonight | 5 |
| June 14 – 27 1959 | Russ Conway - Roulette | 2 |
| June 28 – July 25 1959 | Bobby Darin - Dream Lover | 4 |
| July 26 – September 5 1959 | Cliff Richard and The Drifters (a.k.a. The Shadows) - Living Doll | 6 |
| September 6 – October 3 1959 | Craig Douglas - Only Sixteen | 4 |
| October 4 – 10 1959 | Jerry Keller - Here Comes Summer | 1 |
| October 11 – 24 1959 | Bobby Darin - Mack The Knife | 2 |
| October 25 – November 28 1959 | Cliff Richard and The Shadows - Travellin' Light | 5 |
| November 29 – December 19 1959 | Adam Faith - What Do You Want | 3** |
| December 13 1959 – January 23 1960 | Emile Ford and The Checkmates - What Do You Want To Make Those Eyes At Me For | 6** |
17 different songs hit number one in the UK during 1959.