This lists songs that hit number one on the charts in the US during 1966. If a song spent nonconsecutive weeks at number one, the number of weeks for each occurrence at the top is shown in parenthesis.
| Date | Artist - Title | Weeks at #1 |
| December 26 1965 – January 1 1966 | Simon and Garfunkel - The Sounds of Silence | 2 (1) |
| January 2 – 15 1966 | Beatles - We Can Work It Out | 3 (2) |
| January 16 – 22 1966 | Simon and Garfunkel - The Sounds of Silence | 2 (1) |
| January 23 – 29 1966 | Beatles - We Can Work It Out | 3 (1) |
| January 30 – February 12 1966 | Petula Clark - My Love | 2 |
| February 13 – 19 1966 | Lou Christie - Lightnin' Strikes | 1 |
| February 20 – 26 1966 | Nancy Sinatra - These Boots Are Made for Walkin' | 1 |
| February 27 – April 2 1966 | Sgt. Barry Sadler - Ballad of the Green Beret | 5 |
| April 3 – 23 1966 | Righteous Brothers - (You're My) Soul and Inspiration | 3 |
| April 24 – 30 1966 | Young Rascals - Good Lovin' | 1 |
| May 1 – 21 1966 | Mamas and Papas - Monday Monday | 3 |
| May 22 – June 4 1966 | Percy Sledge - When A Man Loves A Woman | 2 |
| June 5 – 18 1966 | Rolling Stones - Paint It Black | 2 |
| June 19 – 25 1966 | Beatles - Paperback Writer | 2 (1) |
| June 26 – July 2 1966 | Frank Sinatra - Strangers In The Night | 1 |
| July 3 – 9 1966 | Beatles - Paperback Writer | 2 (1) |
| July 10 – 23 1966 | Tommy James and The Shondells - Hanky Panky | 2 |
| July 24 – August 6 1966 | Troggs - Wild Thing | 2 |
| August 7 – 27 1966 | Lovin' Spoonful - Summer In The City | 3 |
| August 28 – September 3 1966 | Donovan - Sunshine Superman | 1 |
| September 4 – 17 1966 | Supremes - You Can't Hurry Love | 2 |
| September 18 – October 8 1966 | Association - Cherish | 3 |
| October 9 – 22 1966 | Four Tops - Reach Out, I'll Be There | 2 |
| October 23 – 29 1966 | Question Mark and The Mysterians - 96 Tears | 1 |
| October 30 – November 5 1966 | Monkees - Last Train To Clarksville | 1 |
| November 6 – 12 1966 | Johnny Rivers - Poor Side of Town | 1 |
| November 13 – 26 1966 | Supremes - You Keep Me Hangin On | 2 |
| November 27 – December 3 1966 | New Vaudeville Band - Winchester Cathedral | 3 (1) |
| December 4 – 10 1966 | Beach Boys - Good Vibrations | 1 |
| December 11 – 24 1966 | New Vaudeville Band - Winchester Cathedral | 3 (2) |
| December 25 1966 – February 11 1967 | Monkees - I'm A Believer | 7 |
27 different songs hit number one in the US during 1966.
Top 5 Songs of 1966

1: S/Sgt. Barry Sadler - The Ballad Of The Green Berets
2: Association - Cherish
3: Righteous Brothers - (You're My) Soul And Inspiration
4: Four Tops - Reach Out I'll Be There
5: ? & The Mysterians - 96 Tears
2: Association - Cherish
3: Righteous Brothers - (You're My) Soul And Inspiration
4: Four Tops - Reach Out I'll Be There
5: ? & The Mysterians - 96 Tears