This lists songs that hit number one on the charts in the US during 1980. If a song spent nonconsecutive weeks at number one, the number of weeks for each occurrence at the top is shown in parenthesis.
| Date | Artist - Title | Weeks at #1 |
| December 30 1979 – January 5 1980 | KC and the Sunshine Band - Please Don't Go | 1 |
| January 6 – 12 1980 | Rupert Holmes - Escape (Pina Colada Song) | 3 (1) |
| January 13 – February 9 1980 | Michael Jackson - Rock With You | 4 |
| February 10 – 16 1980 | Captain and Tennille - Do That to Me One More Time | 1 |
| February 17 – March 15 1980 | Queen - Crazy Little Thing Called Love | 4 |
| March 16 – April 12 1980 | Pink Floyd - Another Brick in the Wall (Part 2) | 4 |
| April 13 – May 24 1980 | Blondie - Call Me | 6 |
| May 25 – June 21 1980 | Lipps, Inc. - Funkytown | 4 |
| June 22 – July 12 1980 | Paul McCartney - Coming Up (Live at Glasgow) | 3 |
| July 13 – 26 1980 | Billy Joel - It's Still Rock and Roll to Me | 2 |
| July 27 – August 23 1980 | Olivia Newton-John - Magic | 4 |
| August 24 – 30 1980 | Christopher Cross - Sailing | 1 |
| August 31 – September 27 1980 | Diana Ross - Upside Down | 4 |
| September 28 – October 18 1980 | Queen - Another One Bites the Dust | 3 |
| October 19 – November 8 1980 | Barbra Streisand - Woman in Love | 3 |
| November 9 – December 20 1980 | Kenny Rogers - Lady | 6 |
| December 21 1980 – January 24 1981 | John Lennon - (Just Like) Starting Over | 5 |
17 different songs hit number one in the US during 1980.
Top 5 Songs of 1980
1: Blondie - Call Me
2: Pink Floyd - Another Brick In The Wall
3: Olivia Newton-John - Magic
4: Michael Jackson - Rock With You
5: Captain and Tennille - Do That To Me One More Time
2: Pink Floyd - Another Brick In The Wall
3: Olivia Newton-John - Magic
4: Michael Jackson - Rock With You
5: Captain and Tennille - Do That To Me One More Time