This lists songs that hit number one on the charts in the US during 2001. If a song spent nonconsecutive weeks at number one, the number of weeks for each occurrence at the top is shown in parenthesis.
| Date | Artist - Title | Weeks at #1 |
| November 12 2000 – January 27 2001 | Destiny's Child - Independent Women Part 1 | 11 |
| January 28 – February 10 2001 | Shaggy feat. Ricardo "RikRok" Ducent - It Wasn't Me | 2 |
| February 11 – 17 2001 | Outkast - Ms. Jackson | 1 |
| February 18 – March 17 2001 | Joe feat. Mystikal - Stutter | 4 |
| March 18 – 24 2001 | Crazy Town - Butterfly | 2 (1) |
| March 25 – 31 2001 | Shaggy feat. Rayvon - Angel | 1 |
| April 1 – 7 2001 | Crazy Town - Butterfly | 2 (1) |
| April 8 – May 26 2001 | Janet - All For You | 7 |
| May 27 – June 30 2001 | Christina Aguilera, Lil' Kim, Mya and Pink - Lady Marmalade | 5 |
| July 1 – 28 2001 | Usher - U Remind Me | 4 |
| July 29 – August 11 2001 | Destiny's Child - Bootylicious | 2 |
| August 12 – September 1 2001 | Alicia Keys - Fallin' | 6 (3) |
| September 2 – 22 2001 | Jennifer Lopez - I'm Real | 5 (3) |
| September 23 – October 13 2001 | Alicia Keys - Fallin' | 6 (3) |
| October 14 – 27 2001 | Jennifer Lopez - I'm Real | 5 (2) |
| October 28 – December 8 2001 | Mary J. Blige - Family Affair | 6 |
| December 9 – 15 2001 | Usher - U Got It Bad | 6 (1) |
| December 16 2001 – January 12 2002 | Nickelback - How You Remind Me | 4 |
15 different songs hit number one in the US during 2001.
Top 5 Songs of 2001
1: Lifehouse - Hanging By A Moment
2: Alicia Keys - Fallin'
3: Janet - All For You
4: Train - Drops Of Jupiter (Tell Me)
5: Jennifer Lopez feat Ja Rule - I'm Real
2: Alicia Keys - Fallin'
3: Janet - All For You
4: Train - Drops Of Jupiter (Tell Me)
5: Jennifer Lopez feat Ja Rule - I'm Real