This lists songs that hit number one on the charts in the US during 2003. If a song spent nonconsecutive weeks at number one, the number of weeks for each occurrence at the top is shown in parenthesis.
| Date | Artist - Title | Weeks at #1 |
| November 3 2002 – January 25 2003 | Eminem - Lose Yourself | 12 |
| January 26 – February 1 2003 | B2K feat. P. Diddy - Bump, Bump, Bump | 1 |
| February 2 – March 1 2003 | Jennifer Lopez feat. LL Cool J - All I Have | 4 |
| March 2 – May 3 2003 | 50 Cent - In Da Club | 9 |
| May 4 – 24 2003 | Sean Paul - Get Busy | 3 |
| May 25 – June 21 2003 | 50 Cent feat. Nate Dogg - 21 Questions | 4 |
| June 22 – July 5 2003 | Clay Aiken - This Is The Night | 2 |
| July 6 – August 30 2003 | Beyonce Featuring Jay-Z - Crazy In Love | 8 |
| August 31 – September 27 2003 | Nelly, P. Diddy and Murphy Lee - Shake Ya Tailfeather | 4 |
| September 28 – November 29 2003 | Beyonce feat. Sean Paul - Baby Boy | 9 |
| November 30 – December 6 2003 | Ludacris feat. Shawna - Stand Up | 1 |
| December 7 2003 – February 7 2004 | OutKast - Hey Ya! | 9 |
12 different songs hit number one in the US during 2003.
Top 5 Songs of 2003

1: 50 Cent - In Da Club
2: R. Kelly - Ignition
3: Sean Paul - Get Busy
4: Beyonce feat Jay-Z - Crazy In Love
5: 3 Doors Down - When I'm Gone
2: R. Kelly - Ignition
3: Sean Paul - Get Busy
4: Beyonce feat Jay-Z - Crazy In Love
5: 3 Doors Down - When I'm Gone