This lists songs that hit number one on the charts in the US during 2010. If a song spent nonconsecutive weeks at number one, the number of weeks for each occurrence at the top is shown in parenthesis.
| Date | Artist - Title | Weeks at #1 |
| December 27 2009 – February 27 2010 | Ke$ha - TiK ToK | 9 |
| February 28 – March 13 2010 | Black Eyed Peas - Imma Be | 2 |
| March 14 – 20 2010 | Taio Cruz feat. Ludacris - Break Your Heart | 1 |
| March 21 – April 24 2010 | Rihanna - Rude Boy | 5 |
| April 25 – May 8 2010 | B.o.B feat. Bruno Mars - Nothin' On You | 2 |
| May 9 – 15 2010 | Usher feat. will.i.am - OMG | 4 (1) |
| May 16 – 22 2010 | Eminem - Not Afraid | 1 |
| May 23 – June 12 2010 | Usher feat. will.i.am - OMG | 4 (3) |
| June 13 – July 24 2010 | Katy Perry feat. Snoop Dogg - California Gurls | 6 |
| July 25 – | Eminem feat. Rihanna - Love the Way You Lie | 7 |
9 different songs hit number one so far in the US during 2010.